In 1999, Dr. Osborne came to Baylor College of Medicine from the University of Texas Health Science Center at San Antonio and started what is now known as the Lester and Sue Smith Breast Center, a unit of the Dan L Duncan Comprehensive Cancer Center. He brought his expertise in breast cancer patient care and research and a National Cancer Institute (NCI) Specialized Programs of Research Excellence grant in breast cancer, now one of the longest-running grants of its kind.

In 2004. Dr. Osborne was named director of what would become the Dan L. Duncan Comprehensive Cancer Center at Baylor. Under Dr. Osborne’s leadership, the Duncan Cancer Center earned the prestigious NCI designations of “Cancer Center” in 2007 and then of “Comprehensive Cancer Center” in 2015. The “Comprehensive” designation recognizes the Duncan Cancer Center for its depth and breadth of clinical and basic science research, clinical research trials and service to cancer patients from diverse populations in the community. Since the initial NCI designation as a “Cancer Center” in 2007, annual research grant funding at the Duncan Cancer Center has increased to $170 million from $99 million.

Today, the Duncan Cancer Center has more than 450 members, including laboratory researchers; surgical, medical and radiation oncologists; radiologists; and pathologists providing comprehensive cancer care. Physicians provide patient care at multiple affiliated hospitals in Houston, including Baylor St. Luke’s Medical Center, Texas Children’s Hospital, Harris Health System and the Michael E. DeBakey Veterans Affairs Medical Center.